2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE
2-DI-1-ASP
CAS: 2156-29-8
Molecular Formula: C16H19IN2
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Names and Identifiers
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Physico-chemical Properties
| Molecular Formula | C16H19IN2 |
| Molar Mass | 366.24 |
| Melting Point | 280°C (dec.)(lit.) |
| Solubility | DMSO : 25 mg/mL (68.26 mM; Need ultrasonic) |
| BRN | 3776369 |
| Storage Condition | -20℃ |
| Use | 2-Di-1-ASP (Compound 18a) is a monostyryl dye widely used as a mitochondrial staining and groove-binding fluorescent probe for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA. |
| In vitro study | 2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms ( c-kit2 , c-kit87up , c-myc ). |
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10 |
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Reference
| Reference Show more | 1. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889. |
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.73 ml | 13.652 ml | 27.304 ml |
| 5 mM | 0.546 ml | 2.73 ml | 5.461 ml |
| 10 mM | 0.273 ml | 1.365 ml | 2.73 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
2-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE - Reference Information
| biological activity | 2-Di-1-ASP (DASPI, 2M2PM, D 308, Compound 18a) is a monostyryl dye, it can be used as a mitochondrial stain and a groove-binding fluorescent probe for G-quadruplex (G4) DNA. |
Last Update：2024-04-09 20:49:11
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